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A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin

20 Feb 2020

Abstract excerpt

Gastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription factors SOX2 and OCT4 promote stemness, our approach was to isolate stem-like cells in human gastric cancer cell lines using a traceable reporter system based on SOX2/OCT4...

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PMID: 32093282
DOI: 10.3390/cancers12020495

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