Article

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic Fibrosis

2020-05-05

Abstract excerpt

<h4>Introduction/Abstract</h4> Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts in excess of 70,000 people globally. People with CF experience multi-organ dysfunction resulting from aberrant electrolyte transport across polarized epithelia due to mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene. CF-related lung disease is by far the most significant de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fee9c88-abd7-575c-b433-f88b8584ac8f
DOI: 10.1101/2020.05.01.072876

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic FibrosisDOI 10.1101/2020.05.01.072876Read

Identifying novel therapeutic targets in cystic fibrosis through advanced single-cell transcriptomics analysisSemantic proximity Read

Single Cell RNAseq Reveals A Critical Role of Chloride Channels in Airway DevelopmentSemantic proximity Read

A single-cell atlas of the human healthy airwaysSemantic proximity Read

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epitheliumSemantic proximity Read

Evidence for altered immune-structural cell crosstalk in cystic fibrosis revealed by single cell transcriptomicsSemantic proximity Read

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epitheliumSemantic proximity Read

Distinct airway progenitor cells drive epithelial heterogeneity in the developing human lungSemantic proximity Read

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epitheliumSemantic proximity Read

Single-Cell RNA Sequencing Reveals New Basic and Translational Insights in the Cystic Fibrosis Lung.Semantic proximity Read

Single-cell atlas of bronchoalveolar lavage from preschool cystic fibrosis reveals new cell phenotypesSemantic proximity Read

Pharmacological correction of CFTR improves systemic inflammation and lung disease in Cystic Fibrosis but does not correct a basic defect in lung repairSemantic proximity Read

A Single-Cell Atlas of the Human Healthy AirwaysSemantic proximity Read