Article

Electrical activity between skin cells regulates melanoma initiation

2021-12-21

Abstract excerpt

<h4>Summary</h4> Oncogenes can only initiate tumors in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells in the microenvironment can endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation by BRAF V600...

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Literature Corpus work: 7fdec184-e175-5216-af8d-6c44c8ed28d5
DOI: 10.1101/2021.12.19.473393

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