Article

Suppression of the DNA repair enzyme NEIL2 promotes persistent inflammation and genomic damage in subjects with stable COPD and during severe exacerbations

2024-09-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease that is an independent risk factor for lung cancer. NEIL2, a DNA glycolase involved in DNA repair during transcription, has also been associated with an increased incidence of malignancies in humans. NEIL2 knockout mouse models have demonstrated increased inflammation and oxida...

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Literature Corpus work: 7fb8dd40-d1e0-59ed-a319-001f2809fe7d
DOI: 10.21203/rs.3.rs-4849668/v1

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