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Article

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences

1 Mar 2011

Abstract excerpt

Lung tissue from COPD patients displays oxidative DNA damage. The present study determined whether oxidative DNA damage was randomly distributed or whether it was localized in specific sequences in either the nuclear or mitochondrial genomes. The DNA damage-specific histone, gamma-H2AX, was detected immunohistochemically in alveolar wall cells in lung tissue from COPD patients but not control subjects. A...

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PMID: 21660298
DOI: 10.2147/copd.s15922

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