Article
State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer.
Proceedings of the American Thoracic Society - 1 Aug 2006
Brody Jerome S, Spira Avrum
Abstract excerpt
Both lung cancer and chronic obstructive pulmonary disease (COPD) are associated with cigarette smoking, which, by generating reactive oxidant species, induces a chronic inflammatory state in the lung. Activation, particularly of nuclear factor-kappaB, occurs in both cancer and COPD, and expression of a number of genes is altered in both diseases. In lung cancer, DNA damage, lack of DNA repair, and genomic...
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