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Article

Immune and genetic mechanisms in COPD: possible targets for therapeutic interventions.

Current drug targets - 1 Feb 2013

Tzortzaki Eleni G, Papi Alberto, Neofytou Eirini, Soulitzis Nikolaos, Siafakas Nikolaos M

Abstract excerpt

Genetic, immune and environmental interactions are key elements for the development of COPD. Cigarette smoking is considered the primary risk factor initiating inflammatory cascades in genetically susceptible individuals. The "danger signals" elicited by the injured cells of non-specific immunity induce the downstream activation of proinflammatory cascades and antigen-specific adaptive immune responses. The...

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Identifiers

PMID: 23256714
DOI: 10.2174/1389450111314020002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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