Article

Single-cell sequencing uncovers clonal dynamics profiles and therapeutic resistance biomarkers in relapsed and refractory peripheral T-cell lymphoma

2025-12-13

Abstract excerpt

<title>Abstract</title> <p>Peripheral T-cell lymphoma (PTCL) is a heterogeneous and highly aggressive subtype of non-Hodgkin lymphoma. Approximately 30% of patients develop relapsed or refractory (R/R) PTCL due to disease recurrence or failure to achieve complete remission after first-line therapy. The molecular and cellular mechanisms underlying treatment resistance in R/R PTCL patients remain unclear, despite t...

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Literature Corpus work: 7fa421c2-a96a-5be7-9f66-31c9b063a6b4
DOI: 10.21203/rs.3.rs-8304942/v1

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