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Article

Discrete genetic subtypes and tumor microenvironment signatures correlate with peripheral T-cell lymphoma outcomes.

Leukemia - 1 May 2025

Suehara Yasuhito, Sakamoto Kana, Fujisawa Manabu, Fukumoto Kota, Abe Yoshiaki, Makishima Kenichi, Suma Sakurako, Sakamoto Tatsuhiro, Hattori Keiichiro, Sugio Takeshi, Kato Koji, Akashi Koichi, Matsue Kosei, Narita Kentaro, Takeuchi Kengo, Carreras Joaquim, Nakamura Naoya, Chiba Kenichi, Shiraishi Yuichi, Miyano Satoru, Ogawa Seishi, Chiba Shigeru, Sakata-Yanagimoto Mamiko

Abstract excerpt

Peripheral T-cell lymphoma (PTCL) exhibits a diverse clinical spectrum, necessitating methods to categorize patients based on genomic abnormalities or tumor microenvironment (TME) profiles. We conducted an integrative multiomics study in 129 PTCL patients, performing whole-exome sequencing and identifying three genetic subtypes: C1, C2, and C3. C2 was characterized by loss of tumor suppressor genes and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40164718
DOI: 10.1038/s41375-025-02563-0
PMCID: PMC12055585

Genes

C2
C3
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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