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Targeted mutational profiling of peripheral T-cell lymphoma not otherwise specified highlights new mechanisms in a heterogeneous pathogenesis

3 Sept 2014

Abstract excerpt

Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is a diagnosis of exclusion making up the largest fraction (25–30%) of PTCL. Although traditionally considered a ‘wastebasket’ diagnosis, recent gene-expression results suggest the disease comprises two biologic sub-entities characterized by expression of the transcription factors GATA3 or TBX21 and their target genes. 1 The mutational landscape of...

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PMID: 25257991
DOI: 10.1038/leu.2014.261

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