Back to search

Article

Genetically-proxied lower PAR1 and renal phenotypes: a drug-target Mendelian Randomization study

2024-08-09

Abstract excerpt

In clinical trials, the anti-protease-activated receptor-1 (PAR1) therapy, vorapaxar, has been tested as a treatment for nephrotic syndrome (NS). This study aimed to investigate the causal relationship of PAR1 (encoded by the gene F2R ) with renal phenotypes using drug-target Mendelian randomization (MR). First, we performed colocalization analyses to confirm whether PAR1/ F2R expression instruments were shared be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7f8a083b-70cc-579c-8a8c-a777193373e4
DOI
10.1101/2024.08.08.24311690
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genetically-proxied lower PAR1 and renal phenotypes: a drug-target Mendelian Randomization studyDOI 10.1101/2024.08.08.24311690
Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation.Semantic proximity
Comprehensive Druggable Genome-Wide Mendelian Randomization Reveals Therapeutic Targets for Kidney DiseasesSemantic proximity
Mendelian Randomization Identifies Circulating Proteins APOM and TNXB as Biomarkers for Steroid Sensitive Nephrotic SyndromeSemantic proximity
Therapeutic Targets for Diabetic Kidney Disease: Proteome-Wide Mendelian Randomization and Colocalization Analyses.Semantic proximity
Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development.Semantic proximity
Circulating inflammatory proteins may be potential drug targets for Idiopathic Membranous Nephropathy: proteome-wide Mendelian Randomization and colocalization analysisSemantic proximity
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysisSemantic proximity
Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease.Semantic proximity
Membranous Nephropathy: Muti-omics Mendelian randomization and colocalization analysisSemantic proximity
Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genesSemantic proximity
Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis.Semantic proximity
Genetically proxied therapeutic inhibition of kidney function drug targets and type 2 diabetes in Africans: A Mendelian randomization studySemantic proximity
Select a neighboring publication to make it the new centre.