Article

IKKα promotes lung adenocarcinoma growth through activation of ERK signaling via DARPP-32-mediated inhibition of PP1 activity

2022-07-10

Abstract excerpt

Non–small cell lung cancer (NSCLC) accounts for 80-85% cases of lung cancer cases. Diagnosis at advanced stages is common, after which therapy-refractory disease progression frequently occurs. Therefore, a better understanding of the molecular mechanisms that control NSCLC progression is necessary to develop new therapies. Overexpression of IκB kinase α (IKKα) in NSCLC correlates with poor patient survival. IKKα i...

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Literature Corpus work: 7f481ea6-3ac3-58ab-b5bb-1ccfebf11e7d
DOI: 10.1101/2022.07.08.499350

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