Article

Protein Compositional Ratio Representation (PCRR) Systematically Improves Human Disease Prediction

2025-12-01

Abstract excerpt

Plasma proteomics captures a functional snapshot of human physiology; yet, most machine learning models treat protein abundances as independent variables, ignoring the fact that biological systems and proteomic measurements are inherently compositional. Many molecular processes depend not on absolute concentrations but on relative balances: receptor–ligand stoichiometry, enzyme–substrate ratios, and homeostatic fe...

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Literature Corpus work: 7eee29c7-be99-5429-85d1-60038eea0a4e
DOI: 10.1101/2025.11.29.691286

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