Article

Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs

2025-10-24

Abstract excerpt

<h4>Summary</h4> Genetic modification of human induced pluripotent stem cells (hiPSCs) is a powerful approach to measure and manipulate the cellular processes underlying differentiation and disease. Conventional genetic engineering of hiPSC lines requires a laborious process involving transfection, selection and expansion that can result in karyotypic abnormalities or transgene silencing during differentiation, l...

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Identifiers and source

Literature Corpus work: 59e10530-ce20-554b-b527-93fbcf08f7db
DOI: 10.1101/2025.10.24.684179

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