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Validation of optogenetic approach to investigate fatigable weakness using a zebrafish model of <i>syt2</i> congenital myasthenic syndrome

2026-06-04

Abstract excerpt

Congenital myasthenic syndromes (CMS) are rare inherited diseases of the neuromuscular junction (NMJ). There are 40 identified CMS genes, but many patients go without genetic diagnosis, which suggests new genes have yet to be discovered and characterised. Here, we describe an optogenetic approach to study fatigable muscle weakness and NMJ function in larval zebrafish to facilitate screening approaches for uncoveri...

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Literature Corpus work
7eb5c2d2-24a4-557c-b044-371e86848079
DOI
10.64898/2026.05.30.728923
Open publication

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Validation of optogenetic approach to investigate fatigable weakness using a zebrafish model of <i>syt2</i> congenital myasthenic syndromeDOI 10.64898/2026.05.30.728923
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