Article

Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker pad

2018-11-19

Abstract excerpt

The functional state of denervated muscle is a critical factor in the ability to restore movement after injury- or disease-related paralysis. Here we used peripheral optogenetic stimulation and transcriptome profiling in the mouse whisker system to investigate the time course of changes in neuromuscular function following complete unilateral facial nerve transection. While most skeletal muscles rapidly lose functi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82497ce2-8663-5190-90c1-7c578b17675d
DOI: 10.1101/473298

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optogenetic and transcriptomic interrogation of enhanced muscle function in the paralyzed mouse whisker padDOI 10.1101/473298Read

A Workflow for Spatial Transcriptomic Analysis from Intra-operative Human Skeletal Muscle BiopsiesSemantic proximity Read

Single Cell Deconstruction of Muscle Stem Cell Heterogeneity During Aging Reveals Sensitivity to the Neuromuscular JunctionSemantic proximity Read

Use of laser microdissection in the investigation of facial motoneuron and neuropil molecular phenotypes after peripheral axotomy.Semantic proximity Read

Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscleSemantic proximity Read

Deleterious impacts of inactivity and beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne Muscular DystrophySemantic proximity Read

Examining Muscle Regeneration in Zebrafish Models of Muscle Disease.Semantic proximity Read

Targeting <i>Tmem63b</i> and <i>Piezo2</i> in C-fiber low threshold mechanoreceptor: limitation of <i>Vglut3</i> -IRES- <i>Cre</i>Semantic proximity Read

The MuSK-BMP pathway regulates synaptic Nav1.4 localization and muscle excitabilitySemantic proximity Read

Gene-environment interaction elicits dystonia-like features and impaired translational regulation in a DYT-TOR1A mouse model.Semantic proximity Read

Bioengineered model of the human motor unit with physiologically functional neuromuscular junctionsSemantic proximity Read

Validation of optogenetic approach to investigate fatigable weakness using a zebrafish model of <i>syt2</i> congenital myasthenic syndromeSemantic proximity Read

Na <sub>V</sub> 1.1 is essential for proprioceptive signaling and motor behaviorsSemantic proximity Read