Article
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy.
Nature communications - 1 Jan 2013
Horstick Eric J, Linsley Jeremy W, Dowling James J, Hauser Michael A, McDonald Kristin K, Ashley-Koch Allison, Saint-Amant Louis, Satish Akhila, Cui Wilson W, Zhou Weibin, Sprague Shawn M, Stamm Demetra S, Powell Cynthia M, Speer Marcy C, Franzini-Armstrong Clara, Hirata Hiromi, Kuwada John Y
Abstract excerpt
Excitation-contraction coupling, the process that regulates contractions by skeletal muscles, transduces changes in membrane voltage by activating release of Ca(2+) from internal stores to initiate muscle contraction. Defects in excitation-contraction coupling are associated with muscle diseases. Here we identify Stac3 as a novel component of the excitation-contraction coupling machinery. Using a zebrafish...
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