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Article

Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans.

Scientific reports - 29 Jan 2016

Hwang Hyundoo, Barnes Dawn E, Matsunaga Yohei, Benian Guy M, Ono Shoichiro, Lu Hang

Abstract excerpt

The sarcomere, the fundamental unit of muscle contraction, is a highly-ordered complex of hundreds of proteins. Despite decades of genetics work, the functional relationships and the roles of those sarcomeric proteins in animal behaviors remain unclear. In this paper, we demonstrate that optogenetic activation of the motor neurons that induce muscle contraction can facilitate quantitative studies of muscle...

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PMID: 26822332
DOI: 10.1038/srep19900
PMCID: PMC4731793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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