Article

Domain-interface dynamics of CFTR revealed by stabilizing nanobodies

2019-06-14

Abstract excerpt

Abstract The leading cause of cystic fibrosis (CF) is the deletion of phenylalanine 508 (F508del) in the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutation affects the thermodynamic stability of the domain and the integrity of the interface between NBD1 and the transmembrane domain leading to its clearance by the quality control system. Here, we d...

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Literature Corpus work: 98b5156d-ce51-50a2-9da9-8c5290ba9ffe
DOI: 10.1038/s41467-019-10714-y

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