Article

Loss of ESE3/EHF is sufficient to promote cell plasticity, transformation and androgen-independent status in the early stage of prostate carcinogenesis

2025-11-30

Abstract excerpt

Phenotypic plasticity enables tumor progression and treatment resistance. However, its timing and underlying mechanisms are poorly understood. Here, we demonstrate that cell plasticity can emerge early during prostate cancer development, resulting from the knockout of the epithelial-specific ETS transcription factor EHF in prostate epithelial cells. Inspecting the transcriptome of human prostate cancers, we identi...

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Literature Corpus work: 7e9c6ae5-f559-53de-9dc7-32dad9a1e061
DOI: 10.1101/2025.11.26.690649

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