The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment.

doi:10.18632/oncotarget.12525

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Article

The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment.

Oncotarget - 22 Nov 2016

Albino Domenico, Civenni Gianluca, Rossi Simona, Mitra Abhishek, Catapano Carlo V, Carbone Giuseppina M

Abstract excerpt

Metastatic prostate cancer represents a yet unsolved clinical problem due to the high frequency of relapse and treatment resistance. Understanding the pathways that lead to prostate cancer progression is an important task to prevent this deadly disease. The ETS transcription factor ESE3/EHF has an important role in differentiation of human prostate epithelial cells. Loss of ESE3/EHF in prostate epithelial cells...

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Share to Cell Self Renewal
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-6

Share to Janus Kinase 2

Share to Neoplastic Stem Cells

Share to RNA, Small Interfering

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Identifiers

PMID: 27732936
DOI: 10.18632/oncotarget.12525
PMCID: PMC5363547

Genes

EHF
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.