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Modulating the Kynurenine pathway or sequestering toxic 3-hydroxykynurenine protects the retina from light induced damage in <i>Drosophila</i>

2022-09-11

Abstract excerpt

Tissue health is regulated by a myriad of exogenous or endogenous factors. Here we investigated the role of the conserved Kynurenine pathway (KP) in maintaining retinal homeostasis in the context of light stress in Drosophila melanogaster . cinnabar, cardinal and, scarlet , are fly genes that encode different steps in the KP. Along with white , these genes are known regulators of brown pigment (ommochrome) bio...

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Literature Corpus work
82ee84b2-613b-5611-a7bc-26aa126afd5f
DOI
10.1101/2022.09.10.507411
Open publication

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