Article

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

2021-12-21

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) emerged into humans in 2012, causing highly lethal respiratory disease. The severity of disease may be in part because MERS-CoV is adept at antagonizing early innate immune pathways – interferon (IFN) production and signaling, protein kinase R (PKR), and oligoadenylate synthetase ribonuclease L (OAS/RNase L) – generated in response to viral double-stranded (d...

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Literature Corpus work: 7e91d28e-509f-56f7-bc4f-d8b0a66855e0
DOI: 10.1101/2021.12.20.473564

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