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Article

Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013

Zhang Rong, Jha Babal K, Ogden Kristen M, Dong Beihua, Zhao Ling, Elliott Ruth, Patton John T, Silverman Robert H, Weiss Susan R

Abstract excerpt

Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2',5'-oligoadenylate (2-5A) synthetases (OASs) and ribonuclease (RNase) L are components of a potent host antiviral pathway. We previously showed that murine coronavirus (MHV) accessory protein ns2, a 2H phosphoesterase superfamily member, is a phosphodiesterase (PDE) that cleaves 2-5A,...

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Identifiers

PMID: 23878220
DOI: 10.1073/pnas.1306917110
PMCID: PMC3740845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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