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Causal relationship between gut microbiota and rheumatoid arthritis: a two-sample Mendelian randomisation study.

Clinical and experimental rheumatology - 1 Jan 2024

Gou Yifan, Zhang Jingxi, Li Chun'e, Liu Ye, Hui Jingni, Zhou Ruixue, Kang Meijuan, Liu Chen, Wang Bingyi, Shi Pangxing, Wen Yan, Zhang Feng

Abstract excerpt

OBJECTIVES: To assess whether there is a bidirectional causal relationship between the composition of gut microbiota and rheumatoid arthritis (RA), and to identify specific pathogenic bacterial taxa via the Mendelian randomisation (MR) analysis. METHODS: We acquired single nucleotide polymorphisms (SNPs) associated with the composition of gut microbiota (n=18,340) and with RA (n=331,313) from publicly available...

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PMID: 37812479
DOI: 10.55563/clinexprheumatol/p9ig7c

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