Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators

Abstract excerpt

We propose microbiome disease "architectures": linking >1 million microbial features (species, pathways, and genes) to 7 host phenotypes from 13 cohorts using a pipeline designed to identify associations that are robust to analytical model choice. Here, we quantify conservation and heterogeneity in microbiome-disease associations, using gene-level analysis to identify strain-specific, cross-disease, positive and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bioinformatics and Genomic Networks
• Share to Gut microbiota and health
• Share to Helicobacter pylori-related gastroenterology studies