Article
Alterations in the gut microbiome implicate key taxa and metabolic pathways across inflammatory arthritis phenotypes.
Science translational medicine - 26 Jul 2023
Thompson Kelsey N, Bonham Kevin S, Ilott Nicholas E, Britton Graham J, Colmenero Paula, Bullers Samuel J, McIver Lauren J, Ma Siyuan, Nguyen Long H, Filer Andrew, Brough India, Pearson Claire, Moussa Caroline, Kumar Vinod, Lam Lilian H, Jackson Matthew A, Pawluk April, Kiriakidis Serafim, Taylor Peter C, Wedderburn Lucy R, Marsden Brian, Young Stephen P, Littman Dan R, Faith Jeremiah J, Pratt Arthur G, Bowness Paul, Raza Karim, Powrie Fiona, Huttenhower Curtis
Abstract excerpt
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has been implicated in inflammatory conditions, but large-scale metagenomic evaluations have not yet traced the routes by which immunity in the gut affects inflammatory arthritis. To characterize the community structure and associated functional processes driving gut microbial involvement in arthritis, the Inflammatory Arthritis...
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