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Article

Analysis of TP53 mutation status in human cancer cell lines: a reassessment.

Human mutation - 1 Jun 2014

Leroy Bernard, Girard Luc, Hollestelle Antoinette, Minna John D, Gazdar Adi F, Soussi Thierry

Abstract excerpt

Tumor-derived cell lines play an important role in the investigation of tumor biology and genetics. Across a wide array of studies, they have been tools of choice for the discovery of important genes involved in cancer and for the analysis of the cellular pathways that are impaired by diverse oncogenic events. They are also invaluable for screening novel anticancer drugs. The TP53 protein is a major component of...

Topics

Cell Line, Tumor
Databases, Genetic
Humans
Internet
Mutation
Neoplasms
Software
Tumor Suppressor Protein p53

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24700732
DOI: 10.1002/humu.22556
PMCID: PMC4451114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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