Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

Abstract excerpt

Cancers that retain wild type TP53 presumably harbor other clonal alterations that permitted their precursors to bypass p53-mediated growth suppression. Consequently, studies that employ TP53-wild type cancer cells and their isogenic derivatives may systematically fail to appreciate the full scope of p53 functionality. Several TP53 phenotypes are known to be absent in the widely used isogenic HCT116 colorectal...

Topics

• Humans
• Tumor Suppressor Protein p53
• Telomerase
• Phenotype
• Cell Proliferation
• Cellular Senescence
• Cell Line, Tumor
• HCT116 Cells
• Gene Expression Regulation, Neoplastic
• Colorectal Neoplasms