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Dual toxicity of voriconazole in a CYP2C19 poor metabolizer: A case analysis of Life-threatening neutropenia and hepatocellular injury

2025-12-23

Abstract excerpt

Voriconazole, a first-line therapy for invasive aspergillosis, exhibits variable pharmacokinetics due to CYP2C19 polymorphisms. However, severe hematological toxicity, particularly life-threatening neutropenia, remains under-recognized. The concomitant occurrence of dual severe organ toxicities in CYP2C19 poor metabolizers (PMs) poses a significant clinical challenge. Here, we report a case of a 71-year-old Chine...

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Literature Corpus work
7e80b79b-2afd-57e3-bce1-2dc8277d4abc
DOI
10.22541/au.176650572.24010040/v1
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