Article

Lipodystrophy and recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

2025-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is a salient feature of skin fibrosis, and is followed by accumulation of extracellular matrix (ECM). Lipodystrophy syndromes, often associated with metabolic co-morbidities, are estimated to affect 1 in 20,000 people. We recently showed that fibrosis-associated lipodystrophy is dependent on sustained Wnt signaling, but the mechani...

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Literature Corpus work: f090f1c8-1760-5658-925f-8c7e6c197f1f
DOI: 10.1101/2025.09.24.678215

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