Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A lipase-independent pathway of lipid release and immune modulation by adipocytes

28 Feb 2019

Abstract excerpt

To meet systemic metabolic needs, adipocytes release fatty acids and glycerol through the action of neutral lipases. Here, we describe a secondary pathway of lipid release from adipocytes that is independent of canonical lipolysis. We found that adipocytes release exosome-sized, lipid-filled vesicles (AdExos) that become a source of lipid for local macrophages. Adipose tissue from lean mice released ~1% of its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Adipose Tissue and Metabolism
Share to Lipid metabolism and biosynthesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30819964
DOI: 10.1126/science.aaw2586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A lipase-independent pathway of lipid release and immune modulation by adipocytesPMID 30819964Read ↗

Secretion and transfer of adipose lipoprotein lipase utilizes neutral sphingomyelinase 2 generated exosomesSemantic proximity Read ↗

Lipid accumulation in adipose tissue-resident iNKT cells contributes to an inflammatory phenotype.Semantic proximity Read ↗

Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological ConditionsSemantic proximity Read ↗

Large adipocytes alter mode of lipid release and promote breast cancer malignancySemantic proximity Read ↗

Exosome Trafficking Is a Key Regulator of Adipocyte ThermogenesisSemantic proximity Read ↗

Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)Semantic proximity Read ↗

LAM/TREM2 <sup>+</sup> macrophages release extracellular vesicles and extracellular lipid droplets which modulate the phenotype of recipient macrophages and homeostasis of skeletal muscle cellsSemantic proximity Read ↗

Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation.Semantic proximity Read ↗

Adipose tissue macrophages: implications for obesity-associated cancerSemantic proximity Read ↗

Current understanding of the role of microRNAs from adipose-derived extracellular vesicles in obesitySemantic proximity Read ↗

Exosome and Macrophage Crosstalk in Sleep-Disordered Breathing-Induced Metabolic DysfunctionSemantic proximity Read ↗

Breaking fat: The regulation and mechanisms of lipophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.