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Article

Mast-cell driven dermal white adipose tissue remodeling amplifies inflammation and fibrosis in atopic dermatitis

2026-01-13

Abstract excerpt

<title>Abstract</title> <p> Atopic dermatitis (AD) is characterized by type-2 inflammation, dermal mast-cell (MC) infiltration and progressive dermal fibrosis, but the stromal drivers remain unclear. Using the MC903-induced AD-like mouse model, we show that dermal white adipose tissue (dWAT) undergoes rapid lipolysis and reactive fibrosis concurrent with MC accumulation and activation within dWAT. Single-cell RN...

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Literature Corpus work
f0efd7a6-dc0e-525a-bec1-3ff9273efdc4
DOI
10.21203/rs.3.rs-8377256/v1
Open publication

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Mast-cell driven dermal white adipose tissue remodeling amplifies inflammation and fibrosis in atopic dermatitisDOI 10.21203/rs.3.rs-8377256/v1
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