Article
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis.
Protein & cell - 1 Jan 2022
Yang Weili, Guo Xiangyu, Tu Zhuchi, Chen Xiusheng, Han Rui, Liu Yanting, Yan Sen, Wang Qi, Wang Zhifu, Zhao Xianxian, Zhang Yunpeng, Xiong Xin, Yang Huiming, Yin Peng, Wan Huida, Chen Xingxing, Guo Jifeng, Yan Xiao-Xin, Liao Lujian, Li Shihua, Li Xiao-Jiang
Abstract excerpt
In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease (PD). However, difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1. Here we report that PINK1 kinase form is selectively expressed in the human...
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