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Article

Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype.

Neuroscience bulletin - 1 Sept 2021

Li Hao, Wu Shihao, Ma Xia, Li Xiao, Cheng Tianlin, Chen Zhifang, Wu Jing, Lv Longbao, Li Ling, Xu Liqi, Wang Wenchao, Hu Yingzhou, Jiang Haisong, Yin Yong, Qiu Zilong, Hu Xintian

Abstract excerpt

Whether direct manipulation of Parkinson's disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue. Here, we used an adeno-associated virus serotype 9 (AAV9)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 genes in the substantia nigras (SNs) of two monkey groups: an old group and a middle-aged group. After the operation, the old group...

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Identifiers

PMID: 34165772
DOI: 10.1007/s12264-021-00732-6
PMCID: PMC8423927

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