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Article

PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys.

Zoological research - 18 Jul 2021

Chen Zhen-Zhen, Wang Jian-Ying, Kang Yu, Yang Qiao-Yan, Gu Xue-Ying, Zhi Da-Long, Yan Li, Long Cheng-Zu, Shen Bin, Niu Yu-Yu

Abstract excerpt

Mutations of PTEN-induced kinase I (PINK1) cause early-onset Parkinson's disease (PD) with selective neurodegeneration in humans. However, current PINK1 knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotypes observed in PD patients. This suggests that generating PINK1 disease models in non-human primates (NHPs) that are close to humans is essential to investigate the...

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Identifiers

PMID: 34213093
DOI: 10.24272/j.issn.2095-8137.2021.023
PMCID: PMC8317192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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