Article

Copper chelation reprograms the tumour microenvironment to enhance immune checkpoint blockade therapy in preclinical mesothelioma

2026-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint blockade provides durable benefit to only a minority of patients with pleural mesothelioma. Here we investigated whether targeting copper homeostasis could enhance anti-tumour immunity and improve responses to immune checkpoint blockade. Copper homeostasis genes were upregulated in human mesothelioma, localised to malignant and stromal cells but downregulated in lymphocytes. In...

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Literature Corpus work: 7e521e69-3345-5cb8-b00a-afc8054e08d1
DOI: 10.64898/2026.07.28.740857

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