Article

Copper chelation inhibits TGF- <i>β</i> pathways and suppresses epithelial-mesenchymal transition in cancer

2022-10-06

Abstract excerpt

Copper is a trace element essential to cellular function with elevated levels implicated in cancer progression. Clinical trials using copper chelators are associated with improved patient survival, however, the molecular mechanisms by which copper depletion inhibits tumor progression are poorly understood. This remains a major hurdle to the clinical translation of copper chelators. Epithelial-mesenchymal transitio...

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Literature Corpus work: c38effe8-1640-5f3a-b30b-5018a7cc0311
DOI: 10.1101/2022.10.03.510707

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