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Molecular Mechanism of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma

2025-03-31

Abstract excerpt

Mesothelioma is characterized by the inactivation of tumor suppressor genes, with frequent mutations in neurofibromin 2 (NF2), BRCA1-associated protein 1 (BAP1), and cyclin-dependent kinase inhibitor 2A (CDKN2A). These mutations lead to disruptions in the Hippo signaling pathway and histone methylation, promoting tumor growth. NF2 mutations result in Merlin loss, leading to uncontrolled cell proliferation, whereas...

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Literature Corpus work
05089302-a582-559e-a457-5be6f8a3cac5
DOI
10.20944/preprints202503.2357.v1
Open publication

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