Article

Altered striatal long-term potentiation in the eIF4E- TG ASD mouse model

2026-03-06

Abstract excerpt

Autism spectrum disorder (ASD) is associated with deficits in synaptic plasticity across brain regions. While striatal dysfunction is observed in various mouse models of ASD, the effect of ASD-associated genes on striatal plasticity has not been well characterised. We previously showed that overexpression of the SFARI ASD risk gene eIF4E in transgenic (eIF4E-TG) mice produces ASD-like behaviours and impairs dorsa...

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Literature Corpus work: 7deeb9eb-80bd-504c-9dc2-4d8b09ea7e24
DOI: 10.64898/2026.03.04.709616

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