Article

Hyper-Glycosylation as a Central Metabolic Driver of Alzheimer’s Disease

2025-05-05

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by devastating degenerative decline. Metabolic disruptions are widely observed, yet their involvement in the molecular etiology of AD remains underexplored. Utilizing spatial metabolomics, lipidomics, and glycomics in both mouse models and human post-mortem samples, we identified a hyper-glycosylation phenotype as a hallmark of AD. To investiga...

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Literature Corpus work: 7dc03130-dc5a-58df-805d-bd47e443a0a2
DOI: 10.1101/2025.04.30.651461

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