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Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin

9 Oct 2018

Abstract excerpt

Whether non-integrated viral DNAs distribute randomly or target specific positions within the higher-order architecture of mammalian genomes remains largely unknown. Here we use Hi-C and viral DNA capture (CHi-C) in primary human hepatocytes infected by either hepatitis B virus (HBV) or adenovirus type 5 (Ad5) virus to show that they adopt different strategies in their respective positioning at active chromatin....

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PMID: 30323189
DOI: 10.1038/s41467-018-06739-4

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