Article

GPX3 supports ovarian cancer tumor progression <i>in vivo</i> and promotes expression of GDF15

2024-01-29

Abstract excerpt

<h4>Objective</h4> We previously reported that high expression of the extracellular glutathione peroxidase GPX3 is associated with poor patient outcome in ovarian serous adenocarcinomas, and that GPX3 protects ovarian cancer cells from oxidative stress in culture. Here we tested if GPX3 is necessary for tumor establishment in vivo and to identify novel downstream mediators of GPX3’s pro-tumorigenic function. <h...

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Literature Corpus work: 7d89f2f7-0f62-5980-a9ce-769cd6b83e68
DOI: 10.1101/2024.01.24.577037

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