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Article

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.

Cell reports - 7 Mar 2017

Medrano Mauricio, Communal Laudine, Brown Kevin R, Iwanicki Marcin, Normand Josee, Paterson Joshua, Sircoulomb Fabrice, Krzyzanowski Paul, Novak Marian, Doodnauth Sasha A, Saiz Fernando Suarez, Cullis Jane, Al-Awar Rima, Neel Benjamin G, McPherson John, Drapkin Ronny, Ailles Laurie, Mes-Massons Anne-Marie, Rottapel Robert

Abstract excerpt

The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression analysis of cell-surface markers in a panel of HGSC cell lines to identify genes that are critical to their survival. We report that the tetraspanin CD151 contributes...

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Identifiers

PMID: 28273451
DOI: 10.1016/j.celrep.2017.02.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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