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Article

Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer.

Biochemical pharmacology - 1 Feb 2021

Nirgude Snehal, Choudhary Bibha

Abstract excerpt

Glutathione peroxidases are well known antioxidant enzymes. They catalyze the reduction of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 GPxs, GPx3, a highly conserved protein and a major ROS scavenger in plasma, has been well studied and confirmed to play a vital role as a tumor suppressor in most cancers. Additionally, this gene is known to be epigenetically regulated. It...

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Identifiers

PMID: 33310051
DOI: 10.1016/j.bcp.2020.114365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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