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GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2

25 Jul 2025

Abstract excerpt

BACKGROUND: Due to the lack of effective targeted therapies and the high likelihood of acquired resistance, triple-negative breast cancer (TNBC) remains one of the deadliest cancers affecting women globally. Investigating the mechanism underlying TNBC's resistance to platinum-based chemotherapy and identifying new therapeutic targets are urgent priorities. METHODS: The expression level of GPX3, cisplatin...

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PMID: 40713734
DOI: 10.1186/s12964-025-02356-z

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