Article
Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation.
Biochemical and biophysical research communications - 23 Sept 2017
Guo Jun, Lam Lloyd T, Longenecker Kenton L, Bui Mai H, Idler Kenneth B, Glaser Keith B, Wilsbacher Julie L, Tse Chris, Pappano William N, Huang Tzu-Hsuan
Abstract excerpt
Cancer cells have an unusually high requirement for the central and intermediary metabolite nicotinamide adenine dinucleotide (NAD+), and NAD+ depletion ultimately results in cell death. The rate limiting step within the NAD+ salvage pathway required for converting nicotinamide to NAD+ is catalyzed by nicotinamide phosphoribosyltransferase (NAMPT). Targeting NAMPT has been investigated as an anti-cancer strategy,...
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