Article

Genetic Algorithm with Rank Selection optimises robust parameter estimation for systems biology models

2022-02-23

Abstract excerpt

<h4>ABSTRACT</h4> The ability to reliably predict and infer cellular responses to environmental exposures would offer a major advance in the investigation of immune regulation in health and disease. One possible approach is the use of in silico modelling. Design of such a mathematical kinetic model would be based on existing knowledge of a biological system and utilise a partial data set to parameterise. However...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d799c69-9136-5d35-8558-b8ae5463730d
DOI: 10.1101/2022.02.22.481394

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Algorithm with Rank Selection optimises robust parameter estimation for systems biology modelsDOI 10.1101/2022.02.22.481394Read

Genetic Algorithms for model refinement and rule discovery in a high-dimensional agent-based model of inflammationSemantic proximity Read

Identifying Integrative Molecular Pathways for Predictive Modeling of Infectious DiseaseSemantic proximity Read

GAMES: A dynamic model development workflow for rigorous characterization of synthetic genetic systemsSemantic proximity Read

LASSIM - a network inference toolbox for genome-wide mechanistic modelingSemantic proximity Read

Molecular Pathways Resultant in Fever due to Inhibitory Effects of Binding PGE2 to Glucocorticoid ReceptorsSemantic proximity Read

Benchmark Problems for Dynamic Modeling of Intracellular ProcessesSemantic proximity Read

A quantitative systems pharmacology workflow towards optimal design and biomarker stratification of atopic dermatitis clinical trialsSemantic proximity Read

Using constraints and their value for optimization of large ODE systems.Semantic proximity Read

A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signalingSemantic proximity Read

Mathematical design of optimal treatment schedules for atopic dermatitis based on a mechanistic modelling approachSemantic proximity Read

Pharmacodynamic model of PARP1 inhibition and global sensitivity analyses can lead to cancer biomarker discoverySemantic proximity Read

Analysis of Mechanistic Pathway Models in Drug Discovery: p38 PathwaySemantic proximity Read