Article

A quantitative systems pharmacology workflow towards optimal design and biomarker stratification of atopic dermatitis clinical trials

2023-07-03

Abstract excerpt

<h4>Background</h4> The development of atopic dermatitis (AD) drugs is confronted by many disease phenotypes and trial design options, which are hard to explore experimentally. <h4>Objective</h4> Optimize AD trial design using simulations. <h4>Methods</h4> We constructed a quantitative systems pharmacology (QSP) model of AD and standard of care (SoC) treatments and generated a phenotypically diverse virtual popula...

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Literature Corpus work: c90e06fb-e7e7-5bf5-bb81-937cf4f2ebfe
DOI: 10.1101/2023.07.01.23292105

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