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IN SILICO OPTIMIZATION OF BIOMIMETIC NANOPARTICLE KINETICS FOR SEPSIS MANAGEMENT: A COMPUTATIONAL PHARMACOLOGY FRAMEWORK FOR RATIONAL DESIGN

2026-01-19

Abstract excerpt

<h4>Background</h4> Sepsis-induced mortality is frequently driven by the systemic dissemination of pore-forming toxins (PFTs), such as Staphylococcus aureus alpha-hemolysin. Biomimetic “nanosponges” which are nanoparticles coated in red blood cell (RBC) membranes have emerged as a promising detoxification strategy. However, current methods rely largely on empirical iteration, often failing to optimize the compet...

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Literature Corpus work
aa5ae91c-e1da-5f2c-9779-55e11cc09547
DOI
10.64898/2026.01.17.26344326
Open publication

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IN SILICO OPTIMIZATION OF BIOMIMETIC NANOPARTICLE KINETICS FOR SEPSIS MANAGEMENT: A COMPUTATIONAL PHARMACOLOGY FRAMEWORK FOR RATIONAL DESIGNDOI 10.64898/2026.01.17.26344326
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